Here are some useful things to know for managing an Exim 4 server. This assumes a prior working knowledge of SMTP, MTAs, and a UNIX shell prompt.
Message-IDs and spool files
The message-IDs that Exim uses to refer to messages in its queue are mixed-case alpha-numeric, and take the form of: XXXXXX-YYYYYY-ZZ. Most commands related to managing the queue and logging use these message-ids.
There are three -- count 'em, THREE -- files for each message in the spool directory. If you're dealing with these files by hand, instead of using the appropriate exim commands as detailed below, make sure you get them all, and don't leave Exim with remnants of messages in the queue. I used to mess directly with these files when I first started running Exim machines, but thanks to the utilities described below, I haven't needed to do that in many months.